Guidelines & Interactions for Medication-Assisted Treatment

Medication-assisted treatment (MAT) supports recovery with proven medications like methadone and buprenorphine, backed by clear safety guidance. This page breaks down key MAT guidelines and common medication interactions. At Health Care Resource Centers (HCRC), you’ll receive structured care and straightforward next steps.

Why MAT Guidelines Matter

MAT medications such as methadone and buprenorphine are carefully prescribed to reduce cravings and withdrawal. Following treatment guidelines helps protect your health and ensures your medication works as intended.

Clear guidelines support:

  • Medication safety and effectiveness
  • Lower risk of side effects or interactions
  • Better long-term stability in treatment

Medications Used in MAT

MAT uses FDA-approved medications as part of a structured treatment plan that also includes counseling and support. Each medication works differently. Your provider helps determine the safest option for you.

Methadone
Buprenorphine

Important Drug Interactions to Know

Some medications and substances can interact with MAT medications. Always tell your providers that you are in a medication-assisted treatment program.

Methadone Interactions

Some drugs may reduce methadone’s effect or increase drowsiness. Dose adjustments may be needed. Use caution with:

  • Benzodiazepines such as Xanax or Valium
  • Alcohol or sedative medications
  • Certain seizure, HIV, or antibiotic medications

Buprenorphine and Suboxone Interactions

Injecting or misusing Suboxone can cause sudden withdrawal due to naloxone. Use caution with:

  • Benzodiazepines and alcohol
  • Other opioid pain medications
  • Sedatives or sleep medications

MAT Side Effects and What to Expect

Many people have few or no side effects. If side effects do occur, they are often mild and can improve as your body adjusts or as your dose is fine-tuned. If something feels uncomfortable or unexpected, your provider can help.

Common methadone side effects may include:

  • Constipation or sweating
  • Drowsiness or sleep changes
  • Dry mouth or headache

Common buprenorphine side effects may include:

  • Constipation or nausea
  • Headache or fatigue
  • Sleep disturbances

Safe Use, Storage, and Daily Activities

Simple daily habits help your MAT medication work safely and consistently.

Safe Storage
Driving
Travel

Coordinating Care With Other Providers

For safe treatment, all medical providers should know you are in medication-assisted treatment. This includes dentists, surgeons, and emergency providers. With your consent, coordinated care helps avoid medication conflicts and supports better outcomes.

Getting Started With MAT

Starting MAT means learning how your medication works and how to use it safely. At Health Care Resource Centers, you’ll receive clear education, medication guidance, and case management support to help with real-life needs that can affect treatment, all in a structured outpatient setting.

Accredited and Trusted Care

All HCRC centers are federally certified, state licensed, and accredited by the Commission on Accreditation of Rehabilitation Facilities (CARF). This recognition reflects our commitment to safety, quality, and continuous improvement.

Frequently Asked Questions (FAQs)

What is medication-assisted treatment (MAT)?

MAT combines medications like methadone or buprenorphine with counseling and support. It helps reduce cravings and withdrawal so you can focus on recovery.

Can I take other medications while in MAT?

Often, yes. Some medications can interact with methadone or buprenorphine. Share a full list of prescriptions, OTC meds, and supplements so your care team can guide you safely.

Is methadone addictive?

Methadone is an opioid, but when used as prescribed in a program, it supports stability and reduces harm.

Is Suboxone an opioid?

Suboxone contains buprenorphine, a partial opioid agonist, plus naloxone. It helps reduce cravings and withdrawal and is designed to lower misuse risk when taken as directed.

Can MAT medications affect driving?

Many people drive normally once they are stable on the right dose. If you feel drowsy or unfocused, avoid driving and let your provider know so your plan can be adjusted.

How do I start a MAT program near me?

Contact HCRC to schedule an assessment. You’ll receive clear next steps and help choosing a treatment option that fits your needs and routine.